Dynamic Key Med(DKM)--- Active Compounds
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Research Areas：
Proteases
Apoptosis
Chromatin/Epigenetics
Metabolism
MAPK Signaling
Tyrosine Kinase
DNA Damage/DNA Repair
PI3K/Akt/mTOR
Microbiology & Virology
Ubiquitination/ Proteasome
JAK/STAT Signaling
TGF-β / Smad Signaling
Angiogenesis
GPCR/G protein
Endocrinology and Hormones
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Others
Antibody-drug Conjugate/ADC Related
Antioxidants
Peptides
Default
Research Grade Biosimilar
ATPase
Cancer Biology
Cell Cycle/Checkpoint
Epigenetics
Infectious Disease
Natural Products
Active Pharmaceutical Ingredients
PROTAC
Stem Cell
Signaling Pathways：
PLK
Src
Microtubule/Tubulin
PAK
ATM/ATR
Aurora Kinase
PERK
Ras
Podophyllotoxin （CAS#518-28-5 Cat#D910521）
CAS#：
518-28-5
Formula：
C₂₂H₂₂O₈
Molecular Weight：
414.41
Solubility：
DMF: 15 mg/ml,DMSO: 15 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 0.14 mg/ml,PBS (pH 7.2): slightly soluble
Biological Target：
Antineoplastic
Storage：
Store at 2-8°C
Microtubule/Tubulin
$56.00
万
PF-3758309 （CAS#898044-15-0 Cat#D807094）
Cat#：
D807094
CAS#：
898044-15-0
Formula：
C₂₅H₃₀N₈OS
Molecular Weight：
490.62
Solubility：
≥ 24.53 mg/mL in DMSO, ≥ 101.4 mg/mL in EtOH with ultrasonic and warming
Biological Target：
PAK4 inhibitor
Storage：
Store at -20°C
PAK
$62.00
万
Poloxin （CAS#321688-88-4 Cat#D913543）
CAS#：
321688-88-4
Formula：
C₁₈H₁₉NO₃
Molecular Weight：
297.35
Solubility：
≥ 14.85 mg/mL in DMSO, ≥ 40.3 mg/mL in EtOH with ultrasonic and warming
Biological Target：
PLK1 inhibitor
Storage：
Store at -20°C
PLK
$65.00
万
G-5555 （CAS#1648863-90-4 Cat#D918720）
CAS#：
1648863-90-4
Formula：
C₂₅H₂₅ClN₆O₃
Molecular Weight：
493
Solubility：
DMSO : ≥ 170 mg/mL (321.11 mM)
Biological Target：
G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis.
Storage：
Store at -20°C
PAK
$56.00
万
Poloxime （CAS#17302-61-3 Cat#D914735）
CAS#：
17302-61-3
Formula：
C₁₀H₁₃NO₂
Molecular Weight：
179.22
Solubility：
Soluble in DMSO
Biological Target：
polo-like kinase 1 （PLK) analogue
Storage：
Store at -20°C
PLK
$379.00
万
CP-466722 （CAS#1080622-86-1 Cat#D916489）
CAS#：
1080622-86-1
Formula：
C₁₇H₁₅N₇O₂
Molecular Weight：
349.35
Solubility：
≥ 4.36mg/mL in DMSO with ultrasonic and warming
Biological Target：
ATM inhibitor,potent and reversible
Storage：
Store at -20°C
ATM/ATR
$92.00
万
FRAX1036 （CAS#1432908-05-8 Cat#D910251）
CAS#：
1432908-05-8
Formula：
C₂₈H₃₂ClN₇O
Molecular Weight：
518.05
Solubility：
DMF: 1 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,Ethanol: 0.33 mg/ml
Biological Target：
p21-activated kinase I (PAK1) inhibitor
Storage：
Store at -20°C
PAK
$17.00
万
ISRIB (trans-isomer) （CAS#1597403-47-8 Cat#D915462）
CAS#：
1597403-47-8
Formula：
C₂₂H₂₄Cl₂N₂O₄
Molecular Weight：
451.34
Solubility：
≥ 8.96 mg/mL in DMSO with gentle warming
Biological Target：
PERK inhibitor,potent and selective
Storage：
Store at -20°C
PERK
$98.00
万
PIR 3.5 （CAS#6088-51-3 Cat#D912107）
CAS#：
6088-51-3
Formula：
C₂₀H₁₄O₂S₂
Molecular Weight：
350.45
Solubility：
<26.28mg/ml in DMSO
Biological Target：
negative control of IPA 3, a Pak1 inhibitor
Storage：
Store at -20°C
PAK
$106.00
万
Cyclapolin 9 （CAS#40533-25-3 Cat#D913268）
CAS#：
40533-25-3
Formula：
C₉H₄F₃N₃O₄S
Molecular Weight：
307.21
Solubility：
<7.68mg/ml in DMSO
Biological Target：
PLK1 inhibitor
Storage：
Store at -20°C
PLK
$18.00
万
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